The Teratology Society adopts resolution on folic acid fortification

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Teratology Society Consensus Statement on use of folic acid to reduce the risk of birth defects.

Neural tube defects are common and severe birth defects that include the fatal condition anencephaly and the disabling condition spina bifida. Recent randomized controlled studies, (Crandall et al., ’95; Czeizel and Dudas, ’92; MRC Vitamin Study Research Group, ’91) have shown that women who consume folic acidcontaining supplements, while eating their usual diets, have 50–75% fewer infants with...

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Folic acid fortification and congenital heart disease.

Background: Low plasma folate concentrations in pregnancy are associated with preterm birth. Here we show an association between preconceptional folate supplementation and the risk of spontaneous preterm birth. Methods and Findings: In a cohort of 34,480 low-risk singleton pregnancies enrolled in a study of aneuploidy risk, preconceptional folate supplementation was prospectively recorded in th...

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Contemporary Issues Surrounding Folic Acid Fortification Initiatives

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected a...

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Folic Acid—Benefits, Risks, and Food Fortification

My last column addressed folic acid and its benefits for pregnant women and their offspring. Specifically, the column focused on: a) folate for women at childbearing age and folate’s role in preventing both neural tube defects and other fetal abnormalities and learning and behavior problems in the offspring, and b) the possible benefits of folic acid for cancer prevention. This article continue...

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Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

BACKGROUND Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory fortification. However due to safety considerations this decision is now on hold. Before mandatory fortification goes ahead, existing levels of unmetabolised folic acid and their ...

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ژورنال

عنوان ژورنال: Birth Defects Research

سال: 2020

ISSN: 2472-1727

DOI: 10.1002/bdr2.1687